Mikhail Blagosklonny Explained the Causes of Aging and the Benefits of Rapamycin

Mikhail Blagosklonny, a leading researcher in aging and cancer, put forward a new conceptual framework that describes the various actors of aging. The theory stated that the aging is not caused by untargeted molecular damage. It is due to hypertrophy and hyperfunction – an unsuitable continuation to the growth developments, especially mTOR signaling. By the theory, mTOR that is acting as adaptive in the growth stages creates detrimental consequences and becomes a quasi-program in the adulthood in the later stages of people. This quasi-programs do not terminate during the adulthood, and ability to create an off-switch usually diminishes with age.It is also said that the molecular damages would still occur without considering the hyperfunction, but the theory states that the damage is irrelevant of aging. The new theory put forward by Blagosklonny is more appealing as conventional models such as molecular damage and oxidative stress theories have many identified deficiencies. The hyperfunction theory explains the aging as a casual chain starting from hypertrophy to various macroscopic pathologies and ultimately to death. Interestingly, Blagosklonny proposed the new theory of aging in a series of papers that started in the year 2006 and continued till 2011.

Blagosklonny further states that rapamycin is great in reducing the effects and aging and can significantly increase the healthy lifespan of the humans. The drug was isolated from a bacterium found in Easter Island in the year 1972 and initially used as an anti-fungal agent. The drug is useful in treating a number of diseases including cancer, coronary stent coating, tuberous sclerosis complex, hemolytic-uremic syndrome, systemic lupus erythematosus, and more. Dr. Blagosklonny conducts extensive research on its effects on aging and found that it can increase the longevity of a person significantly.He conducted tests on mice and showed that the aging mice get the ability to fight tuberculosis in a better way. The initial tests conducted on elder humans showed that they started showing immunological rejuvenation when administered rapamycin before any influenza vaccination.

Blagosklonny claims that the drug can add excellent overall health benefits in the later stages of human life by curing a number of diseases. Now, the scientists are in the process of verifying its overall effects and conducting tests on marmoset monkey. Various researches showed that rapamycin could also be used to treat Alzheimer’s disease as it reduced the brain lesions and prevented the cognitive issues in mice.Mikhail Blagosklonny is an oncology professor at Roswell Park Institute for Cancer located in New York. Before joining Roswell in 2009, he was working as a senior scientist at the Albany-based Ordway Research Institute. In the initial years of his career, Blagosklonny worked at New York Medical College as an associate professor. He secured his M.D. (internal medicine) and Ph.D. in cardiology and experimental medicine from First Pavlov State Medical University. Blagosklonny is collaborating with a number of science journals that are dedicated to both aging and cancer. He is the editor-in-chief of Oncotarget, Aging, and Cell Cycle and published more than 300 articles, book reviews, papers, and more.

Andrew Rolfe Facilitates The Success Of The Ubuntu Education Fund’s Gala Dinner

The Ubuntu Education Fund is a respected organization. Over the years, the management of the same has been helping the needy children in the society. Founded in 1999, the entity has grown from a small charity to a large organization serving many children in the society. Owing to the high number of needy children in the society, Jacob Lief and Malizole “Banks” Gwaxula, decided to open a school campus in Port Elizabeth, South Africa. When they were starting operations, the two deemed it fit to provide the students with education. However, they soon realized that education was not having an impact on most of the children. This way, they conducted a comprehensive research. The study found that most of the children could not realize their dreams in education because of hunger and HIV. It is for this reason that the institution decided to start offering them with nutrition, home stability and healthcare services.

In order to run their operations, the Ubuntu Fund needs money. To this end, the leadership of the Ubuntu Education Fund, led by Andrew Rolfe, organized a gala dinner in London. During the invitation-only event, the attendees were treated to good music and delicious meals. The management of the Fund was optimistic that they would be in a position to raise $ 972, 960. To their surprise, the 300 guests raised more than their set target.

The management of the Ubuntu Education Fund asserted that they would use the money to increase the capacity of their school campus. In addition, they would develop a modern pediatric clinic to cater for the healthcare needs of the needy children. After all these projects have been completed, the Fund will increase the number of disadvantaged students at the campus.

About Andrew Rolfe

Andrew Rolfe is a revered authority at the Ubuntu Fund. Under his leadership, the Fund has been able to enroll more needy students. As the chairperson of the Fund, Rolfe has been at the center of capital-raising activities.

The alumnus of the renowned Harvard Business School has rendered his services for different organizations. Rolfe has worked for Pret A. Manger, the Gap, PepsiCo Restaurants International and Booker Foodservice.

 

InnovaCare Health Boss Dr Shinto

Touted as one of the authority figures in Healthcare provision, Dr Shinto is a man who seems to have won the hearts and minds of all stakeholders in the health sectors. He has managed to take medical care beyond the preconceived notion that accessing medical aid is an expensive affair. This is a single man’s journey through the career ladder from a simple pulmonologist to the Current position that he holds at Innovacare Health. Dr Shinto is currently the Chief Executive Officer (CEO) and president of InnovaCare. It’s one of the leading managed healthcare providers in the country. This was made possible through the able leadership of Dr Shinto

Dr Shinto is no stranger in the medical field having got his B.S from the University of California. Dr Rick Shinto acquired his medical degree from the University of New York and received his MBA from the University of Redlands. He did his internship Southern California and also kick-started his career as a Pulmonologist in Southern California. With over two decades worth of experience in the healthcare sector there are very few people who can boast of such a wonderful track record. His academic intellect and entrepreneurial spirit have seen him occupy some of the most lucrative positions in well-known healthcare management firms.

Before being appointed as the CEO of InnovaCare, Dr Shinto was the CEO of Aventa Inc which is a highly regarded healthcare management firm. He also had appointments as Medical Management´s Vice President before a move to Orange County´s Cal Optimal Health Plan as its Chief Medical Officer. Dr Shinto also worked extensively for NAMM California as its Chief Medical Officer. In the course of his work as a healthcare practitioner, Dr Shinto has also written several works on matters clinical medicine. This is only but a few of the Jobs undertaken while in the health industry.

Dr Shinto attributes his success to teamwork and proper communication channels. This enables seamless flow of information and ensures that everyone is accountable for their actions. There is also a team of experienced, qualified personnel that ensure there is no second guessing of decisions. Interaction with employees of InnovaCare indicate that Dr Shinto is a well respected gentleman who has his workers’ best interest at heart. The desire and willingness to serve is what makes Dr Shinto great for the job and his positive attitude has seen the team at InnovaCare excel in service delivery.

Martavias Bryant’s fantasy football rankings fall as a result of a lack of self-disipline

Pittsburgh Steelers wide receiver Martavias Bryant was selected in the fourth round in the 2014 NFL draft. Every since he was drafted by the Steelers misconduct, poor performance, and injuries have prevented him from transforming into a WR1 with high fantasy football rankings (elite receiver). At 6’4″ 211 pounds and a speed of 4.42, he has the assets to be a serious Ariel threat. There are plenty of fantasy football players that have suffered greatly from selecting Bryant because they thought he would rank high for fantasy football rankings.

In 2014, Bryant sat out six games after suffering an A/C sprain and performing horribly during the offseason. In 2015, he was suspended the first four games for violating the drug policy. In 2016, coaches and fans had high expectations for Bryant, but once again, they were let down. He failed his second drug test and was forced to sit out all season.

The fantasy footballers is a podcast about fantasy football rankings and strategies for picking the best players. The group of guys involved in this project also write articles about fantasy football rankings and injury updates for players.

 

An Event That Covered It All

In a recent annual event held by the Texas Bankers’ Association, Nexbank CEO John Holt spoke out on what he believes should be the next crucial moves for any banking leader to implement with full force. The event was highly inspiring and allowed multiple banking strategists from countless walks of life to offer their input and potential solutions to many current banking dilemmas as well. The event’s overall purpose was to unite banking leaders under one banner, which it appeared to accomplish no less successfully. Mr. Holt was also remembered as an invaluable speaker and discussion panelist; the association hopes to bring him back on board for next year’s conferences as well – and perhaps even a few more after that.

There’s a good chance the members of the Texas Banker’s Association will see more of Mr. Holt in the days to come. Not only are he and his business based in Texas, but they also know every major and minor city surrounding it. Nexbank plans to go all the way at next year’s convention, and Mr. Holt does not plan on being far behind it. New things are coming for the future of Nexbank and for commercial and business banking in Texas as a whole, according to Holt.

Also, Nexbank itself is not planning on leaving the business anytime soon. No, this top banking services provider has been around since 1934 and has not given up the fight ever since, so why stop now? Holt has done a wonderful job in maintaining the company’s brand and reputation both appealing and constantly new to attract all contemporary audiences and clients as well. Equities, investments, CDs and more are available as well: You may learn more at nexbank.com.

Nexbank is FDC approved. Nexbank is an Equal Housing Lender. It’s fully copyrighted.

Roberto Santiago Investments in the Brazilian Shopping Mall Sector

There is no doubt that Roberto Santiago has established massive business interests in the sate of Paraiba, and in particular Joao Pessoa City. He was born on July 16, 1958, in Joao Pessoa. Roberto has invested heavily in the shopping mall industry in the state Paraiba. In 1987, he began the construction of one of the most recognized malls in Joao Pessoa, Roberto Santiago Manaira Shopping, which is considered as the crown jewel of the city. It was completed and launched in 1989. Since then, the mall has recorded massive growth and expansion, leading to numerous additions and redevelopment projects as a way of enhancing complete customer satisfaction.

 

Entertainment, Fun and Leisure

 

Roberto Santiago designed the Manaira Shopping as a haven for fun and entertainment. The mall has diverse options of entertainment for all customers searching for comfort, fun and tranquility whenever they visit the city. Manaira Shopping has vast space reserved for bowling alleys, movie theaters, electronic amusement park, gaming zone, kids’ zone and ballroom.

 

Variety of Entertainment Venues at Manaira Shopping

 

Manaira Shopping is recognized as a pioneer of the electronic amusement park in the city. This venue is called the Game Station, and contains more than 200 gaming machines. The mall has a fully electronic bowling space. Another great highlight of the mall is cinema venues. There are eleven fully equipped cinema halls, having modern and advanced devices for clear and quality movie experience. Other additional features in these cinema halls are 3D and VIP venues as well as the stadium-like arrangement. The venue also has a bar service to offer drinks, candy and pop corns based on individual preferences of movie lovers. There are gyms and fitness centers for those who love working out to keep their bodies healthy.

 

Roberto Santiago designed Manaira Shopping in a similar way world-class shopping centers are constructed in other parts of Brazil. There are banks to cater for the needs of those operating various stores, and also for the customers. In addition, there is a university to offer higher learning to residents of the wider Paraiba state. The Gourmet Space is another amazing avenue at Manaira Shopping that provides moment of tranquility to individuals and their families. This venue serves customers mouth water dishes. Also, there is a food court at the mall serving diverse tastes to both local and foreign visitors.

 

The Domus Hall was launched in 2009, after the mall underwent a major renovation. It is used for various purposes including live concerts, wedding, graduation, conferences and others. The main purpose of Domus Hall is to attract both local and international artists for live performance. It has the mezzanine floor and ground floor. The entire hall can hold nearly 10,000 fans, some seated while others standing.

 

Bumble BFF A Game Changer For Women

After leaving Tinder in 2014, Wolfe launched Bumble another dating app that she co-founded. In the first eight months of operation, more than five million conversations were initiated in Bumble app. The app has its headquarters in Texas and has 35 employees across the world.

Whitney Wolfe recently came up with Bumble BFF which is a subsection of the original app. The app focuses on forming friendships but for women. Many people are searching for the new friendship feature, and Bumble has about 12.5 million users. In the first week in operation, Bumble BFF got more than 1 million swipes.

American women have been found to wait longer to marry and for this reason, friends come in handy for safety, support, companionship and assistance with difficult tasks like moving. Most women in U.S stay single up to 27 years, and this is a long time to stay single and do things by yourself. Bumble BFF was primarily meant for women who have trouble making friends after relocating. After finishing her college, Whitney Wolfe has since lived in six different cities, and it is safe to say that she knows how disorienting a new place can feel.

Career Journey and Education Background

Whitney Wolfe is one of the cofounders of Tinder. After parting ways with Tinder in March 2014, Wolfe developed her own app Bumble. She was born and raised in Salt Lake City, Utah. She began her first business when she was 19 just after she had finished high school. Following the Deepwater Horizon oil spill in the Gulf of Mexico, she began designing and selling bamboo tote bags. Her initial application at the Methodist University in Dallas where she wanted to pursue Marketing was not successful. As her second choice, she opted for SMU to study Global Studies.

Wolfe got her honors at the institution and went on to work at a start-up organization as a sales and marketing agent. She later came up with the idea of a dating app that would go o to change the dating game in the world.

Capital Group Offers Insight on Warren Buffet’s Investment Advice

Warren Buffet is a successful American investor. He recently made news headlines for his investment prediction where he stated that investing  passive index fund is better than investing $1 million in a charity hedge fund. According to Warren, most investment gurus have invested a lot of money in big ventures that cost so much with little to zero profit yields. He is positive about winning a lot of money out of the bet. In response to Warren’s odds, Timothy Armour of Capital Group gave positive insight light of investment. According to Tim, most investment advisers do not offer solid advice when it comes to putting money in the right place. He, therefore, urges investors to consider investing in small dockets that do not require a lot of capital resources because such dockets have long-term benefits.

Timothy Armour

Timothy Armour investment adviser. He has extensive experience in managing funds. His appointment at Capital Group came amidst the loss of Jim Rothenberg. Armour was found to be a better choice for the position following his vast experience and commitment to providing excellent services to the firm. Tim Armour was trusted with the responsibilities of a leading investment management company because he is well versed with the nature of the investment. During his appointment, he was the chairman of the company as well as the lead committee member. He was also in charge of Capital Research in addition to the investment management company.

Roles

Before his appointment, Armour was the deputy manager of Mr. Rothenberg. He worked closely with him while learning all the managerial steps. Armour understands the long term investment fund skills of active management. His reputation precedes being a key decision maker in general operations. Tim has shaped the structure of the company by sharpening the sales operations. His skills in managing funds played a key role in his appointment. Earlier while building his career, Tim worked as an analyst for investment at Capital Group. He was in charge of global telecommunications. He also served the United States service companies. Tim’s persistence in offering investment advice has earned him a leading position at Capital Group.

To know more visit @: medium.com/@timarmour

Anthony Petrello, the Man behind Ground-Breaking PVL Research

At certain points in our lives, we are all faced with negative incidences that truly test our resolve. How we respond to these incidences, show both our character and humanity. For Anthony Petrello, one such incident was the birth of his daughter, Carena, with PVL (periventricular leukomalacia). As a result, she developed certain developmental delays for which medicine is yet to find cures.Nothing prepares a man for such adversity, most especially a very busy one used to having control. Anthony ‘Tony’ Petrello if the CEO, President, and Chairman of the Board of one of the leading drilling contractor companies in the world, Nabor Industries Ltd. As the company’s leader, he oversees over 29 thousand employees and billions of dollars worth of assets. Even a look through his educational and professional journey shows a man that was always in charge of his destiny. He studied at both Harvard and Yale and had a greatly successful stint as a lawyer with the revered law firm, Baker, and McKenzie. He had almost always achieved the objectives he set out to achieve.

Fortunately, while his role at Nabor significantly occupied Mr. Petrello’s time, it did leave him as a man of means. It would, therefore, have been easy for him to cover the cost of managing Carena’s condition. He, however, made a different decision. A decision that would provide hope, not only for Carena but also for other children facing the same challenges.Mr. Petrello and his wife Cynthia decided to invest their own money in pediatric brain research targeted at finding answers to the problems children diagnosed with PVL have. The two arrived at this decision after searching and failing to find a pediatric research institution in the country that runs a similar program.

After identifying the Jan and Dan Neurological Research Institute at Texas Children Hospital as the most appropriate research facility, Anthony and Cynthia donated a substantial $5 million towards the research program. They also committed to raise their donation to $7 and take charge of efforts to raise additional funding and resources.If successful, this research program will positively change the lives of children born with PVL, and their families, all around the world.

How the Internet of Things will Change the Tech World with Jason Hope

The Internet of Things is a modern phenomenon that is going to change the entire world of technology starting this next couple of years. Don’t believe it? Then listen to Jason Hope, an entrepreneur, startup developer of success and technology specialist. According to the expert Jason Hope, the Internet of Things, or IoT for abbreviation, is one of the biggest advancements in the tech industry that society has experienced since the Internet itself.The famous Gartner Inc. published that the Internet of Things would be connected to as many as 25 billion objects by 2020. This insane prediction is not far from the truth, with every big company pursuing the new technology. Google, Microsoft, and Apple are all implementing the new network to their new releases for the future.

This new technology, states Jason Hope, is a way that technology developers found to connect everyday gadgets together with the same way that computers are linked through the network. By using their own connections with each device having a dedicated IP, utensils as common as light bulbs, watches, and refrigerators, will be able to connect with sensors to perform certain actions that were never possible before this new technology. “IoTized products” will now be able to share data among themselves through their network.

Among most promising IoT products, cars are showing great potential to use the technology for the advancement of how cars can perform certain actions without the command of the driver, for example. On the same note, it can be used in streets to send detailed information on the current traffic of that location. The possibilities are endless.

One of the most impressive uses of the Internet of Things that can exemplify what the technology is able to do is how it was implemented by airlines to monitor their airplanes while on the flight.The plane is completely connected to the network, and all parts of the machine are linked to each other and then with the central headquarters. Then, whenever the plane shows signs of malfunctioning, the central receives the warning, and the plane will have its components replaced before it flies again after he landed.Jason Hope, author at Tech.Co where he published his opinions on the subject, is on the board of Arizona Science Center as the director of the group, and he is currently working at Mobile Technology.