Mikhail Blagosklonny, a leading researcher in aging and cancer, put forward a new conceptual framework that describes the various actors of aging. The theory stated that the aging is not caused by untargeted molecular damage. It is due to hypertrophy and hyperfunction – an unsuitable continuation to the growth developments, especially mTOR signaling. By the theory, mTOR that is acting as adaptive in the growth stages creates detrimental consequences and becomes a quasi-program in the adulthood in the later stages of people. This quasi-programs do not terminate during the adulthood, and ability to create an off-switch usually diminishes with age.It is also said that the molecular damages would still occur without considering the hyperfunction, but the theory states that the damage is irrelevant of aging. The new theory put forward by Blagosklonny is more appealing as conventional models such as molecular damage and oxidative stress theories have many identified deficiencies. The hyperfunction theory explains the aging as a casual chain starting from hypertrophy to various macroscopic pathologies and ultimately to death. Interestingly, Blagosklonny proposed the new theory of aging in a series of papers that started in the year 2006 and continued till 2011.
Blagosklonny further states that rapamycin is great in reducing the effects and aging and can significantly increase the healthy lifespan of the humans. The drug was isolated from a bacterium found in Easter Island in the year 1972 and initially used as an anti-fungal agent. The drug is useful in treating a number of diseases including cancer, coronary stent coating, tuberous sclerosis complex, hemolytic-uremic syndrome, systemic lupus erythematosus, and more. Dr. Blagosklonny conducts extensive research on its effects on aging and found that it can increase the longevity of a person significantly.He conducted tests on mice and showed that the aging mice get the ability to fight tuberculosis in a better way. The initial tests conducted on elder humans showed that they started showing immunological rejuvenation when administered rapamycin before any influenza vaccination.
Blagosklonny claims that the drug can add excellent overall health benefits in the later stages of human life by curing a number of diseases. Now, the scientists are in the process of verifying its overall effects and conducting tests on marmoset monkey. Various researches showed that rapamycin could also be used to treat Alzheimer’s disease as it reduced the brain lesions and prevented the cognitive issues in mice.Mikhail Blagosklonny is an oncology professor at Roswell Park Institute for Cancer located in New York. Before joining Roswell in 2009, he was working as a senior scientist at the Albany-based Ordway Research Institute. In the initial years of his career, Blagosklonny worked at New York Medical College as an associate professor. He secured his M.D. (internal medicine) and Ph.D. in cardiology and experimental medicine from First Pavlov State Medical University. Blagosklonny is collaborating with a number of science journals that are dedicated to both aging and cancer. He is the editor-in-chief of Oncotarget, Aging, and Cell Cycle and published more than 300 articles, book reviews, papers, and more.
The Ubuntu Education Fund is a respected organization. Over the years, the management of the same has been helping the needy children in the society. Founded in 1999, the entity has grown from a small charity to a large organization serving many children in the society. Owing to the high number of needy children in the society, Jacob Lief and Malizole “Banks” Gwaxula, decided to open a school campus in Port Elizabeth, South Africa. When they were starting operations, the two deemed it fit to provide the students with education. However, they soon realized that education was not having an impact on most of the children. This way, they conducted a comprehensive research. The study found that most of the children could not realize their dreams in education because of hunger and HIV. It is for this reason that the institution decided to start offering them with nutrition, home stability and healthcare services.
In order to run their operations, the Ubuntu Fund needs money. To this end, the leadership of the Ubuntu Education Fund, led by Andrew Rolfe, organized a gala dinner in London. During the invitation-only event, the attendees were treated to good music and delicious meals. The management of the Fund was optimistic that they would be in a position to raise $ 972, 960. To their surprise, the 300 guests raised more than their set target.
The management of the Ubuntu Education Fund asserted that they would use the money to increase the capacity of their school campus. In addition, they would develop a modern pediatric clinic to cater for the healthcare needs of the needy children. After all these projects have been completed, the Fund will increase the number of disadvantaged students at the campus.
About Andrew Rolfe
Andrew Rolfe is a revered authority at the Ubuntu Fund. Under his leadership, the Fund has been able to enroll more needy students. As the chairperson of the Fund, Rolfe has been at the center of capital-raising activities.
The alumnus of the renowned Harvard Business School has rendered his services for different organizations. Rolfe has worked for Pret A. Manger, the Gap, PepsiCo Restaurants International and Booker Foodservice.
Touted as one of the authority figures in Healthcare provision, Dr Shinto is a man who seems to have won the hearts and minds of all stakeholders in the health sectors. He has managed to take medical care beyond the preconceived notion that accessing medical aid is an expensive affair. This is a single man’s journey through the career ladder from a simple pulmonologist to the Current position that he holds at Innovacare Health. Dr Shinto is currently the Chief Executive Officer (CEO) and president of InnovaCare. It’s one of the leading managed healthcare providers in the country. This was made possible through the able leadership of Dr Shinto
Dr Shinto is no stranger in the medical field having got his B.S from the University of California. Dr Rick Shinto acquired his medical degree from the University of New York and received his MBA from the University of Redlands. He did his internship Southern California and also kick-started his career as a Pulmonologist in Southern California. With over two decades worth of experience in the healthcare sector there are very few people who can boast of such a wonderful track record. His academic intellect and entrepreneurial spirit have seen him occupy some of the most lucrative positions in well-known healthcare management firms.
Before being appointed as the CEO of InnovaCare, Dr Shinto was the CEO of Aventa Inc which is a highly regarded healthcare management firm. He also had appointments as Medical Management´s Vice President before a move to Orange County´s Cal Optimal Health Plan as its Chief Medical Officer. Dr Shinto also worked extensively for NAMM California as its Chief Medical Officer. In the course of his work as a healthcare practitioner, Dr Shinto has also written several works on matters clinical medicine. This is only but a few of the Jobs undertaken while in the health industry.
Dr Shinto attributes his success to teamwork and proper communication channels. This enables seamless flow of information and ensures that everyone is accountable for their actions. There is also a team of experienced, qualified personnel that ensure there is no second guessing of decisions. Interaction with employees of InnovaCare indicate that Dr Shinto is a well respected gentleman who has his workers’ best interest at heart. The desire and willingness to serve is what makes Dr Shinto great for the job and his positive attitude has seen the team at InnovaCare excel in service delivery.